The tumor necrosis factor-alpha (TNF-α)/NF-kappaB/Snail pathway is one of the critical molecular pathways in breast cancer and is involved in many activities related to the tumor cell, including epithelial-mesenchymal transition (86), proliferation (87), angiogenesis (88, 89), invasion, and metastasis (90). The gene discussed is TNF; the disease is breast carcinoma.