(167) followed a hypothesis-driven approach for finding associations between radiomic heterogeneity and genetic aberrations and found that FAT1 somatic mutations were associated with reduced radiomic measures of tumor heterogeneity, possibly clarifying the reason for the previously described better prognosis of patients with human papillomavirus-negative, FAT1-mutated HNSCC. This evidence concerns the gene FAT1 and head and neck squamous cell carcinoma.