A preliminary study (124) that sought to identify other frequent gene mutations in CRC found a significant correlation of tumor location with APC and RASA1 mutation, a significant association of absence of lymph node metastasis with BRCA2 mutation, and a correlation of tumor size with FLT4 mutation, as well as a higher frequency of ATM mutation in patients with a positive circumferential resection margin. The gene discussed is APC; the disease is neoplasm.