GSEA manifested a remarkable activation in cancer-associated signaling pathways was significantly enriched in Cluster2 compared with Cluster1, including epithelial-mesenchymal transition (NES = 2.27, FDR = 5.1e-4), P53 (NES = 1.52, FDR = 4.3e-3), IL6 JAK STAT3 signaling (NES = 2.35, FDR = 5.1e-4), and interferon-gamma response pathways (NES = 2.5, FDR = 5.1e-4) (Figure 5A, Table S4). The gene discussed is STAT3; the disease is cancer.