Pathway analysis showed that DEGs between the KC and KR groups were biosynthesis of amino acids, citrate cycle, valine, leucine and isoleucine biosynthesis, carbon metabolism, cytosolic DNA-sensing pathway, systemic lupus erythematosus, synaptic vesicle cycle, hippo signaling pathway and synthesis and degradation of ketone bodies (P <  0.05, Fig. 3B). This evidence concerns the gene CALCA and systemic lupus erythematosus.