For the V583 treatment group, nine main terms were associated with the response of BeWo cells to invasion, including the MAPK signaling pathway, leukocyte transendothelial migration, p53 signaling pathway, T cell receptor signaling pathway, apoptosis, ErbB signaling pathway, adherens junction, B cell receptor signaling pathway, and pathogenic Escherichia coli infection. This evidence concerns the gene TP53 and escherichia coli infection.