ESR1 and breast carcinoma: It was worth mentioning that DNA2 expression in the breast cancer cohort from bc-GenExMiner was obviously lower in Luminal A breast cancer than in the other subtypes (Figure S1A), while DNA2 expression in the breast cancer cohort from cBioportal was obviously lower in ER+/HER2-low proliferation breast cancer than in the other subtypes (Figure S1B).