Some of the miRs that were identified (miRs-31, -let-7b/e, -222, -145) target known deregulated genes either by mutation or epigenetic regulation (such as promoter methylation) in alcohol and tobacco related HNSCC, such as TP53, MET Proto-Oncogene, Receptor Tyrosine Kinase (MET), Cyclin D2EGFR: epidermal growth factor receptor (CCND2), EGFR, transforming growth factor beta (TGFB), Cyclin Dependent Kinase 6 (CDK6) and Vascular Endothelial Growth Factor (VEGFA). This evidence concerns the gene CCND2 and head and neck squamous cell carcinoma.