Some OVs, like HSV-1 and Coxsackievirus, naturally recognise the overexpressed molecules (herpesvirus entry mediator – HVEM- and CD54, respectively) and can enter in the cancer cell [76, 77]; other OVs can be engineered to directly target unique cell surface receptors, as in the case of adenovirus Ad5/3‐Δ24, which was modified to bind to integrins that are highly expressed on ovarian cancer cells [78]. This evidence concerns the gene ICAM1 and cancer.