To understand the mutual effects of Epimedium, target, disease, and pathway, seven typical pathways were selected to set up an integral network, including the cancer pathway, mitogen-activated protein kinase (MAPK) signaling pathway, PI3K-Akt signaling pathway, HIF-1 signaling pathway, sphingolipid signaling pathway, FoxO signaling pathway, and TNF signaling pathway. The gene discussed is WNK2; the disease is cancer.