BRAF and melanoma: In this study, we used Luminex xMAP technology and 45-plex immunoassay ProcartaPlexTM kits to expand the profile of serum cytokines, in order to explore more cytokines with abnormal concentrations in melanoma patients, evaluate correlations between the cytokine levels and Breslow thickness and BRAF mutation, identify whether the concentrations of cytokines correlated with the survival rate, and determine the critical cytokines in the progression of melanoma.