ACTA1 and Hepatic fibrosis: In addition, the main components of ECM also change from type IV collagen to type I collagen [45], resulting in the increase of density and hardness of ECM, and accumulated ECM also becomes the liver fibrosis tissue microenvironment containing α-SMA, TGF-β1, chemokines such as PDGF, hepatocyte growth factor (HGF), fibroblast growth factor (FGF), epidermal growth factor (EGF), and VEGF [46].