Systemic delivery of two different PBC-relevant compounds (PDC-E2166–181/IAg7- and PDC-E282–96/IAg7-NPs) blunted the progression of liver autoimmunity in NOD.c3c4 mice and (NODxB6.Ifng ARE-Del−/−) F1 mice, which spontaneously develop a form of liver autoimmunity that closely resembles human PBC (4) (Table 1). Here, IFNG is linked to primary biliary cholangitis.