IL10 and type 1 diabetes mellitus: Treatment of NSG mice humanized with PBMCs from DRB1*0301+ and/or DRB1*0401+ T1D patients with NPs displaying human IGRP13–25-DRB1*0301 or human pre-proinsulin (PPI)76-90/DRB1*0401 complexes resulted in the expansion of cognate IL-10-producing CD4+ T-cells co-expressing the Tr1 cell markers CD49b and LAG-3 (Table 1).