Lastly, the work done to date begs the question of whether T-cell types other than CD8+ and CD4+ T-cells, such as invariant Natural Killer T-cells or Mucosal Associated Invariant T-cells, can also be re-programmed into autoimmune disease-suppressing cell types using MHC-based nanomedicines. The gene discussed is CD8A; the disease is autoimmune disease.