In HCC, the immune infiltration of the following cells increased (CD8 naive cells, Tr1 cells, nTreg cells, iTreg cells, Th1 cells, Tfh cells, Central memory cells, DC cells, B cells, and CD4 T cells), while the immune infiltration of these cells decreased (Cytotoxic cells, Exhausted T cells, Th2 cells, Th17 cells, MAIT cells, Monocyte, Macrophage, NK cells, and Neutrophil)(Figure 8H). This evidence concerns the gene CD4 and hepatocellular carcinoma.