RNA-seq revealed that KCs from NASH livers expressed lower amounts of KC specific genes such as Timd4, Pcolce2, and Arg2. Timd4 and Arg2 were also decreased in KCs lacking LXRα knockout, suggesting that loss of LXR activity at their enhancers results in deactivation in the NASH environment (21). The gene discussed is ARG2; the disease is metabolic dysfunction-associated steatohepatitis.