The results of our study would be in line with a concept of impaired T cell immunity as a result of inappropriate resolution of inflammation, as we have indeed observed higher frequencies of activated T cells, of effector memory CD4+ T cells, as well as of induction of co-stimulatory immune checkpoints, which are however accompanied by impaired high levels of inhibitory immune checkpoints, lacking induction of cytokines upon stimulation of CD4+ and CD8+ T cells and impaired control of TT virus replication in patients with liver cirrhosis. The gene discussed is CD4; the disease is cirrhosis of liver.