The present comprehensive immunophenotyping study suggests a relatively early occurrence of impaired cellular immune responses during the course or liver cirrhosis, indicated by strongly reduced numbers of important cell populations of the adaptive and innate immune system like CD4+ T cells, CD8+ T cells, B cells, NK cells, and dendritic cells, which are accompanied by a parallel induction of co-stimulatory and inhibitory immune checkpoints on CD4+ and CD8+ T cells and a lost capacity to induce pro-inflammatory cytokine production. Here, CD4 is linked to cirrhosis of liver.