In a diabetes model with eNOS knockout, inhibition of EGFR attenuated albuminuria, glomerulosclerosis and tubulointerstitial fibrosis, along with a decreased urinary excretion of F2-isoprostane, a marker of oxidative stress (Portero-Otin et al., 2002; Li et al., 2018). This evidence concerns the gene EGFR and diabetes mellitus.