Moreover, the study has further followed up for 5 years and found out that serum level of lncRNA CASC2 is negatively correlated with the incidence of chronic renal failure, supporting that serum level of lncRNA CASC2 may be a specific and reliable biomarker for diagnosis in DKD progression (Wang et al., 2018b). The gene discussed is CASC2; the disease is diabetic kidney disease.