SOD1 and amyotrophic lateral sclerosis: In the SOD1G93A mouse model of ALS, a single intralingual treatment with AAV driving expression of microRNA targeting the superoxide dismutase 1 (SOD1) gene (AAVrh10-H1-miRSOD1) dramatically reduced SOD1 mRNA expression in the tongue, and caused a small (~1 wk) but statistically significant increase in lifespan in females [32].