The reactivity of COS-7-expressed entire functional (ICAM-1 binding) PF11_0521 DBLβ3_D4 domain (immobilized on BioPlex beads) with plasma from children with CM at admission indicate that children with high IgG levels have higher Hb (P = 0.0159) and lower parasitemia (not statistically significant). This evidence concerns the gene ICAM1 and parasitic infectious disease.