Univariate and multivariate logistic regression analyses revealed that elevated indexes of Global CEC as well as Non-ABCA1 CEC, but not ABCA1 CEC, were inversely associated with a large LAVI in AF patients, which was independent from plasma NT-proBNP, LVEF, serum HDL-C, and MPO. This evidence concerns the gene MPO and atrial fibrillation.