For example, ADCY8 (encoding adenylate cyclase 8), a gene involved in multiple pathways, is one of the calcium-sensitive protein isoforms that regulates the phosphorylation of CREB27, which plays an critical role in lymphoma by binding to the promoter of translocated bcl-2 but not normal alleles in FL and transformed lymphomas28. The gene discussed is ADCY8; the disease is lymphoma.