A weighted model (Fig. 2a) comprising age, gender, and four signature genes, including ACRBP (encoding acrosin binding protein), IZUMO1 (encoding Izumo sperm-egg fusion protein 1), CNN2 (encoding calponin 2), and HMG20B (encoding high mobility group 20B), was constructed from the training set to represent the overall 5hmC differential modification pattern between DLBCL and FL. The gene discussed is ACRBP; the disease is diffuse large B-cell lymphoma.