Further, HLA-A*02:06 and HLA-B*44:03 were reported as CM-SJS/TEN with SOC-susceptibility HLA alleles in the Japanese population (OR = 5.6, P = 2.7 × 10−20 and OR = 2.0, P = 1.3 × 10−3; respectively)12. This evidence concerns the gene HLA-B and toxic epidermal necrolysis.