HLA-B*58:01 was also significantly associated with susceptibility to allopurinol-induced SJS/TEN in the Han Chinese, European, and Japanese populations (OR = 580, P = 4.7 × 10−24; OR = 80, P < 10−6; and OR = 62.8, P = 5.4 × 10−12; respectively)9–11. The gene discussed is HLA-B; the disease is toxic epidermal necrolysis.