We previously performed HLA analysis of CM-SJS/TEN with SOC and reported that in Japanese, HLA-A*02:06 and HLA-B*44:03 were significantly associated with CM-SJS/TEN with SOC12, and these associations were not observed in Japanese cases of CM-SJS/TEN without SOC and cold medicine-unrelated (other medicine-related) SJS/TEN with SOC12. This evidence concerns the gene HLA-A and toxic epidermal necrolysis.