In addition to those presented in the previous sections, we found a methylation biomarker (cg21901847, Supplementary Data 3) within NOS3 that is associated with risk for early onset hypertension (β = −0.42, P = 5.3e−10) and CAD (β = 0.04, P = 7.5e−5). This evidence concerns the gene NOS3 and coronary artery disorder.