CXCL8 and neoplasm: By assessing IL8 expression in CM of CAFs cocultured with tumor cells overexpressing PLAU and in CAFs stimulated by CM of tumor cells overexpressing PLAU, we found that PLAU secreted by tumor cells promoted CAFs secretion of IL8 and that PLAU-uPAR specific inhibitor IPR-803 reversed the promotion effect (Fig. 6G–J).