TGFB1 and neoplasm: Similarly, in vivo, subcutaneous tumor xenografts established from co-implantation of WT KYSE-450 and MRC-5 cells pretreated with TGFβ1 and PLAU grew faster than the controls without PLAU pretreatment, and this effect was also inhibited by IPR-803 (Fig. 5E–H).