We detected the expression of uPAR and phosphorylated Akt and p65 in CAFs stimulated by recombinant PLAU, CAFs cocultured with tumor cells overexpressing PLAU, and CAFs treated with CM of tumor cells overexpressing PLAU. The results showed that PLAU upregulates the expression of uPAR and phosphorylated Akt and p65 in CAFs, which can be reduced by IPR-803 (Fig. 6L). This evidence concerns the gene AKT1 and neoplasm.