In the current study, the hepatoprotective effect of WA on GalN/LPS-induced FH depends on the presence of macrophage and partially dependent on NLRP3, which may be explained by the potent inhibitory effects of WA on the adverse events caused by overactivation of the macrophage-NLRP3 axis in the GalN/LPS model. Here, NLRP3 is linked to familial hyperaldosteronism.