In re-expression studies based on human non-small cell lung carcinoma PIDD1−/− A549 cells, Burigotto et al.11 demonstrated that only full-length PIDD1 localizes to centrosome and that, despite occurring independently from centrosome localization, PIDD1 autoproteolysis is strictly required for PIDDosome activation. Here, PIDD1 is linked to non-small cell lung carcinoma.