Elevated 17-OHP can induce hyperglycemia in female mice, and CYP17A1 is suggested to play a role in modulating this effect.9 CYP17A1 converts progesterone to 17-OHP,28 and Lu et al9 proposed that increased 17-OHP levels due to aberrant expression of CYP17A1 in obese mice increase blood glucose via the glucocorticoid (GC) receptor. This evidence concerns the gene CYP17A1 and Hyperglycemia.