WFDC2 plays a role in cancer development (Bingle et al., 2002; Li et al., 2013) and two articles have recently shown Wfdc2 homozygous mutant mice display severe pulmonary phenotypes, including collapsed lungs at perinatal day 1.5 (P1.5) (Nakajima et al., 2019), and alveolar abnormalities, dyspnea and reduced blood oxygen saturation at birth (Zhang et al., 2020), but are otherwise anatomically normal. Here, WFDC2 is linked to cancer.