More importantly, ARHGEF12 expression was also positively associated with immune-related genes, such as CD44, CD47, CD53, CD59, and CD274. Therefore, we suspected that, like its related genes, ARHGEF12 was crucial in the Rho signaling pathway and might be related to diffuse large B cell lymphoma initiation, proliferation, metastasis and treatment, but the deep biological basis of these relationships needs further study. The gene discussed is RHO; the disease is diffuse large B-cell lymphoma.