RHO and cancer: Meantime, ARHGEF12 expression was highly positively correlated with Rho-related genes, such as RHOA, RHOB, CDC42, ROCK1, GNA12, and GNA13. Previous research suggested that Rho signaling pathway was linked to cancer microenvironment, cancer initiation, proliferation, and metastasis, and might incorporate novel biological implications and therapeutic opportunities [52].