ACE and amyloidosis: Recently, ARB use was associated with a reduced rate of amyloid accumulation in the cortex relative to ACE-I use, and this effect was also smaller in APOE ε4 carriers [86], which would be consistent, for example, with the possibility of a more profound and relevant deficit in vascular amyloid clearance with vascular brain aging as a contributing cause of amyloidosis among APOE ε4 non-carriers who were older in this sample [87].