The NLRP3 inflammasome could drive a variety of inflammatory reactions, so persistent and aberrant NLRP3 inflammasome activation contributes to many chronic and degenerative diseases, including type 2 diabetes, Gout, atherosclerosis, Alzheimer’s disease, osteoarthritis, obesity, lupus, macular degeneration, and liver disease [18–20]. This evidence concerns the gene NLRP3 and osteoarthritis.