When we compared the DEGs-baseline and DEGs-TCM, we found that toll-like receptor 5 (TLR5), interleukin-1 receptor antagonist (IL1RN), and solute carrier family 8 member A1 (SLC8A1) were present in both groups (Table 1) and that TLR5, IL1RN, and SLC8A1 were upregulated in sciatica patients at baseline compared with healthy controls and were then downregulated in sciatica patients after integrated TCM treatment compared with baseline. The gene discussed is IL1RN; the disease is Sciatica.