Previous studies unanimously reported that SFRP5 exerted an anti-inflammatory effect by inhibiting the non-canonical Wnt5a/ c-Jun N-terminal kinase (JNK) signaling pathway, therefore playing a key role in repressing the occurrence and development of various diseases including obesity, cardiovascular diseases, and diabetes [10, 11]. This evidence concerns the gene SFRP5 and obesity due to melanocortin 4 receptor deficiency.