ITPR3 and urinary bladder cancer: Then, we further examined ITPR3 expression in bladder cancer cell lines and SV-HUC-1 cells (SV-40 immortalized uroepithelial cells) at both the protein and mRNA levels (Fig. 1c, d) and found that ITPR3 was significantly upregulated in BCa cell lines, especially in 5637 and 253 J cells, compared to SV-HUC-1 cells, which was consistent with the immunohistochemistry (IHC) results.