ITPR3 and urinary bladder cancer: BSP also confirmed that the methylation of the ITPR3 promoter in the normal bladder cell line SVHUC-1 was higher than that in the bladder cancer cell lines (5637 and 253 J) at 43 different CpG sites in 10 clones, and there was also a negative correlation between the mRNA level and methylation level in ITPR3 in bladder cancer.