INS and atrial fibrillation: In the analysis excluding insulin as a proxy of disease severity, the total number of reports for the control group was reduced by 31 % (to 442,303) but the reporting of AF remained significantly lower for SGLT2i (4.8/1000 vs. 9.7/1000; p < 0.001) and the PRR was 0.49 (95% CI 0.43–0.55).