Based on the updated WHO classification of hematological malignancies, MPAL can be divided into several subtypes including MPAL with t(9;22)(q34.1;q11.2); BCR-ABL1, MPAL with t(v;11q23.3); KMT2A rearranged, MPAL, B/myeloid, not otherwise specified (NOS) and MPAL, T/myeloid, NOS [3]. The gene discussed is KMT2A; the disease is mixed phenotype acute leukemia.