It has been describedelsewhere that isocitrate dehydrogenase wildtype (IDHw) AA3 HGGs show a moreaggressive behaviour than isocitrate dehydrogenase mutated (IDHm) AA3 HGGs.2 This might originate from more active tumour cells and with thistheoretically directly influencing the resection margin. This evidence concerns the gene IDH3A and neoplasm.