LGALS3 and infection: Among different galectins, proto-type Gal-1 (14.5 kDa) and chimera-type Gal-3 (26 kDa) are highly expressed and secreted by immune cells, particularly by myeloid cells for which they are crucial for mediating immune cell migration, proliferation, adhesion and signaling.23 Hence, these two galectins are considered as key regulators of immune responses.24–28 During infections, Gal-1 and Gal-3 mediate immune responses primarily by interacting with glycans from pathogen and/or host glycans.