In addition, in 50% of patients with T-ALL, chromosomal translocations affect genes encoding oncogenic transcription factors like TAL1, TAL2, MYC, MYB, LYL1, TLX1 (HOX11), TLX3 (HOX11L2), or HOXA genes, placing these genes under the control of powerful T cell specific activators [114]. The gene discussed is TLX3; the disease is acute lymphoblastic leukemia.