AKT1 and central nervous system cancer: For example, Zheng et al. reported that linc-RA1 knockdown could enhance radiosensitivity by activating autophagy in the glioma cell [42], while Shen et al. found that lincRNA-p21 knockdown enhanced the radiosensitivity of hypoxic tumor cells by inhibiting autophagy via the HIF-1/Akt/mTOR/P70S6K pathway in liver cancer [43].