More specifically, while IFI16 is generally upregulated in HPV+ HNSCC, AIM2 gene expression levels are usually found unchanged in HPV+ HNSCCs with respect to their HPV- counterparts, where this gene is already expressed at high levels (10% vs. 50% of cases, respectively) [12,13]. This evidence concerns the gene IFI16 and head and neck squamous cell carcinoma.