CD274 and non-small cell lung carcinoma: Some of these agents specifically target the programmed cell death 1 receptor (PD-1) (pembrolizumab and nivolumab) or the programmed cell death-ligand 1 receptor (PD-L1) (atezolizumab), and have been approved by EMA and FDA for NSCLC treatment [68,69,70,71,72].