SLC1A2 and amyotrophic lateral sclerosis: In addition, 9 exerted neuroprotective effects by upregulating glutamate transporter-1 (GLT-1) protein levels and GLT-1 and glutamate aspartate transporter (GLAST)-dependent glutamate uptake in astroglial cells and in the cortical tissue of SOD1G93A mice, a transgenic mouse model of amyotrophic lateral sclerosis [60].