TP53 and cancer: Given that neddylation blockade increases the migration of p53-null cancer cell lines [20,25,28], we investigated the relationship between p53 and neddylation blockade in cancer cell migration using different cancer cell lines with wild type p53 or p53-null characteristics (wild type p53: PA-1, MCF7, and A549 cells; p53-null: SKOV-3, PC3, and H1299 cells).