An immunosuppressive microenvironment has been documented in NB, because IL-6 can contribute to a decrease in the antitumor abilities of immune cells, promoting pro-tumorigenic activities, through an autocrine and paracrine action, stimulating the production of immunosuppressive factors such as IL-10, prostaglandin E2, and VEGF; these molecules weaken the innate immune response and also promote tumor vascularization [25,26,27,28,29]. Here, IL6 is linked to neoplasm.