So far, there have been no published studies on the role of IL-8 polymorphisms in NB and only a few studies have investigated the effect of these genetic variants in some diseases, such as asthma, and some types of malignant neoplasms, such as gastric cancer, cancer of the lung, prostate cancer, breast cancer, and glioma [44,46,55,56,57,58,59,60]. The gene discussed is CXCL8; the disease is lung carcinoma.