IFNA1 and systemic sclerosis: Consistently, Kim et al. showed that serum from SSc patients, containing autoantibodies, induced pDC activation and interferon-α (IFN-α) production from healthy cells [7] via the uptake of immune complexes through the Fc-gamma (Fcγ) receptor and the interaction with Toll-like receptors (TLR) [7,8].