Mechanistically, it was found that polyphenols such as quercetin, caffeic and chlorogenic acids acting as ROS scavengers counteract NFκB nuclear translocation by inhibiting the phosphorylation of the inhibitor protein of NFκB (IκB) in human umbilical endothelial cells exposed to hyperglycemia [40] and in ex vivo aortic vessel model exposed to oxidative stress [17]. The gene discussed is NFKB1; the disease is Hyperglycemia.