For example, microarray gene- profiling in cultured CAFs and matched normal fibroblasts from nonsmall cell lung carcinoma (NSCLC) patients, together with data of differentially expressed stromal/CAF genes from various solid tumours revealed significant enrichment in focal adhesion pathways [197], with integrins and FAK posing central nodes [197,198]. This evidence concerns the gene PTK2 and non-small cell lung carcinoma.