Fucoidans have been reported to reduce hyperglycaemia via the inhibition of α-amylase and α-glucosidase, consequently decreasing intestinal absorption of glucose and enhancing the insulin-mediated glucose uptake due to the ability of fucoidans to modulate relevant pharmacological targets including glucose transporter GLUT-4 and AMP-activated protein kinase (AMPK) [36]. Here, INS is linked to Hyperglycemia.