PSEN1 and amyloidosis: Since t-LTP induction protocols can vary with respect to their efficiency to induce synaptic changes and regarding their sensitivity to pathophysiological changes, we compared milder and therefore physiologically relevant low repeat (6×) STDP paradigms with stronger high repeat STDP paradigms (100×/35×), bearing in mind that robust stimulation induced t-LTP might be more sensitive to amyloidosis in adult APP/PS1 mice.