Therefore, we assessed whether t-LTP, evoked by pairing of pre- and postsynaptic APs, at excitatory Schaffer collateral (SC)-CA1 synapses is changed in 6-month-old Alzheimer model mice carrying the KM670/671NL amyloid precursor protein (APP) and the L166P presenilin 1 mutations that are characteristic for familial Alzheimer’s disease (APP⁄PS1 mice; [31]). Here, APP is linked to familial Alzheimer disease.