FCGR2B and systemic lupus erythematosus: However, even with the NSAIDs anti-inflammatory effect, the proinflammatory cytokines and the gene expression of activating FcgRIII in FcgRIIb-/- macrophages were also higher than the WT cells implying more prominent inflammatory responses in FcgRIIb-/- mice that might be an exacerbating factor for lupus activity.